Histamine H₂-Receptor Antagonists

K. Pattichis, M. Kajbaf & J.W. Gorrod

The in vitro metabolism of Mifentidine and two of its derivatives by different species.

Progress in Pharmacology and Clinical Pharmacology 1991 8 31-40
 

M. Kajbaf, J.H. Lamb, S. Naylor, K. Pattichis & J.W. Gorrod

Identification of metabolites derived form the H₂-receptor antagonist Mifentidine using Tandem Mass Spectrometry.

Analytica Chimica Acta 1991 247 (2) 151-159

M. Kajbaf, M. Jahanshahi, K. Pattichis, J.H. Lamb, J.W. Gorrod & S. Naylor

Rapid and efficient purification of Cimetropium bromide and Mifentidine drug metabolite mixtures derived from microsomal incubates for analysis by Mass Spectrometry.

Journal of Chromatography 1992 575 75-85

K. Pattichis, M. Kajbaf & J.W. Gorrod

Intermediates involved in the in vitro metabolism of Mifentidine.

British Journal of Clinical Pharmacology 1992 Proceedings Supplement No. 33 p 228
 

K. Pattichis, L.L. Louca, M. Kajbaf  & J.W. Gorrod

Mifentidine, a formamidine, is metabolised to a urea; a new metabolic pathway.

Medical Science Research 1993 21 747-748 

K. Pattichis & J.W. Gorrod

In vitro studies on the metabolic fate of Mifentidine, a novel histamine H₂-receptor antagonist.

European Journal of Drug Metabolism and Pharmacokinetics 1994 19 (2) (Suppl) 26

K. Pattichis & L.L. Louca

Histamine, histamine H₂-receptors and antagonists, gastric acid secretion and peptic ulcers: an overview.

Drug Metabolism and Drug Interactions 1995 12 (1) 1-36

K. Pattichis, M. Kajbaf & J.W. Gorrod

In vitro studies on the metabolic fate of Mifentidine, a novel histamine H₂-receptor antagonist.

European Journal of Drug Metabolism and Pharmacokinetics 1997 22 (2) 155-164

Red Wine and Migraine

K. Pattichis, J. Jarman, V. Glover, M. Sandler, G. Aislaitner & J.W. Gorrod

Red wine as a migraine trigger: Examination of its effects on ¹⁴C-5-hydroxytryptamine release from platelets.

In: "5-Hydroxytryptamine Mechanisms in Primary Headaches" Ch. 32, pp 242-246, J. Olesen & P.R. Saxena (Eds.), Raven Press Ltd, New York, 1992

K. Pattichis, J. Jarman, A. Clow, V. Glover & M. Sandler

The effect of red wine versus white wine on 5-HT levels in human blood.

Journal of Psychopharmacology 1992 Abstract Book for British Association for Psychopharmacology and European Behavioural Pharmacology Society Joint Meeting A16

V. Glover, K. Pattichis, J. Jarman, R. Peatfield & M. Sandler

How does red wine cause migraine?

9^th Migraine Trust International Symposium 1993 Abstract Book p 49

R. Hering, T. Catarci, V. Glover, K. Pattichis, T.E. Whitmarsh & T.J. Steiner

5-HT in migraine patients with analgesic-induced headache.

9^th Migraine Trust International Symposium 1993 Abstract Book p 94

K. Pattichis, L.L. Louca, J. Jarman, R. Peatfield, M. Sandler & V. Glover

How does red wine cause migraine? 

Chemical News (Cyprus) 1993 6 42-48

K. Pattichis, L.L. Louca, J. Jarman, M. Sandler & V. Glover

Phenolic substances in red wine and release of platelet 5-hydroxytryptamine.

Lancet 1993 341 1104

R. Hering, T. Catarci, K. Pattichis & V. Glover

5-HT in migraine patients with medication-induced headache.

Cephalalgia 1993 13 (6) 410-412

K. Pattichis, L.L. Louca, J. Jarman & V. Glover

Red wine but not white wine can cause a rise in human whole blood 5-Hydroxytryptamine level.

Medical Science Research 1994 22 381-382

K. Pattichis, L.L. Louca & V. Glover

Red wine, but not white, can cause an increase in human whole blood 5-hydroxytryptamine levels.

European Journal of Drug Metabolism and Pharmacokinetics 1994 19 (2) (Suppl) 27

V. Glover, K. Pattichis, J. Jarman, R. Peatfield & M. Sandler

How does red wine cause migraine?

In: "New Advances in Headache Research" 3 Ch 25 pp 145-150, C.F. Rose (Ed.), Smith Gordon & Co Ltd, London, 1994

K. Pattichis, L.L. Louca & V. Glover

Red wine: the effects of phenolic flavonoids on 5-hydroxytryptamine release.

Journal of Psychopharmacology 1994 Abstract Book for British Association for Psychopharmacology and Interdisciplinary Society for Biological Psychiatry Meeting A36

K. Pattichis, L.L. Louca, J. Jarman, M. Sandler & V. Glover

5-Hydroxytryptamine release from platelets by different red wines: implications for migraine.

European Journal of Pharmacology (Environmental Toxicology and Pharmacology Section) 1995 292 (2) 173-177

J. Jarman, K. Pattichis, R. Peatfiled, V. Glover & M. Sandler 

Red wine-induced release of [C-14]5-hydroxytryptamine from platelets of migraine patients and controls.

Cephalalgia 1996 16 (1) 41-43

Parkinson's and Free Oxygen Radicals 

K. Pattichis, L.L. Louca & V. Glover

Mechanism of neuroprotection by the antiparkinsonian agents pergolide and (-)-deprenyl.

European Journal of Drug Metabolism and Pharmacokinetics 1994 19 (2) (Suppl) 28

K. Pattichis, L.L. Louca & V. Glover 

Quantitation of soluble superoxide dismutase in rat striata, based on the inhibition of nitrite formation from hydroxylammmonium chloride.

Analytical Biochemistry 1994 221 428-431

K. Pattichis, L.L. Louca, A. Clow & V. Glover 

Effects of pergolide, (-)-deprenyl and thioridazine on soluble SOD, catalase and glutathione peroxidase in rat striata.

Medical Science Research 1995 23 (11) 733-735

K. Pattichis & V. Glover

Quantitation of soluble superoxide dismutase and its possible role in Parkinson’s disease.

Proceedings of 6^th Chemical Conference on Sustainable Development, Athos Hotel, Halkidiki, Greece, 2000, p180
 

K. Pattichis & V. Glover

New approach in the quantitation of soluble superoxide dismutase in neurotoxic and neuropathological processes.

Biomarkers and Environment 2000 3 (3,4) P14

Drug Development

K. Pattichis

Drug development: from laboratory to man.

Proceedings of ^3rd Joint Chemistry Symposium of Cyprus and Greece,  Ledra Hotel, Nicosia, Cyprus, 1992, pp 256-265

K. Pattichis & L.L. Louca

Medicines and consumer safety.

Proceedings of 5^th Joint Chemistry Symposium of Cyprus and Greece, University of Cyprus, Nicosia, Cyprus, 1996, pp 165-167  

K. Pattichis

Independent contract research organisations: organisation, importance and role for Cyprus and its pharmaceutical industry.

Proceedings of 6^th Joint Chemistry Symposium of Cyprus and Greece, Esperos Village, Rhodes, Greece, 1999, pp 513-515  

Leukocyte Depletion in Cardiovacular Surgery

L.L. Louca, K. Pattichis & R.K. Walesby

The effect of leukocyte depletion on the preservation of the myocardium during cardiopulmonary bypass in humans.

Clinical Trial Protocol, granted Ethics Commitee Approval, London Chest Hospital, UK, 1993

L.L. Louca, K. Pattichis, C. Di Salvo & R.K. Walesby

Effects of leukocyte depletion on myocardial preservation during coronary artery surgery.

Mediterranean Association of Cardiology and Cardiac Surgery 1995 8^th Annual Meeting Abstract Book p 291

C. Di Salvo, L.L. Louca, K. Pattichis, J. Hooper & R.K. Walesby 
Does activated neutrophil depletion on bypass by leukocyte filtration reduce myocardial damage? A preliminary report.
Journal of Cardiovascular Surgery (Torino) 1996 37 (6 Suppl 1) 93-100

Haematological Disease

K. Pattichis & G. Kontoghiorghes 

New approaches in the management of Thalassaemia patients using Deferiprone.

Proceedings of 6^th Joint Chemistry Symposium of Cyprus and Greece, Esperos Village, Rhodes, Greece, 1999, pp 516-517
 

G.J. Kontoghiorghes, K. Pattichis & A. Kolnagou

Worldwide update in L1-deferiprone and new strategies for improving its therapeutic efficiency.

Biomarkers and Environment 2000 3 (3,4) L12

G.J. Kontoghiorghes, K. Pattichis, M. Hadjigavriel & A. Kolnagou

Transfusional iron overload and chelation therapy with defereoxamine and deferiprone (L1).

Transfusion Science 2000 23 211-223

G.J. Kontoghiorghes, M. Sitarou, K. Pattichi and A. Kolnagou
Iron overload toxicity and new therapeutic strategies with the orally effective chelating drug deferiprone (L1). 
Biomarkers and Environment 2001 4 (1) 16-21

G.J. Kontoghiorghes, M. Sitarou, K. Pattichis, M. Hadjigavriel and A. Kolnagou
Present status and future prospects of oral chelation with L1-deferiprone and other orally active chelators.
 SO.S.T.E. Notiziario 2001, Volume 2 (1), pages 98-101

G.J. Kontoghiorghes, M. Sitarou, K. Pattichi, M. Hadjigavriel and A. Kolnagou  
Proceedings of the 11^th ICOC 2001

Kontoghiorghes GJ, Pattichis K, Neocleous K, Kolnagou A.
The design and development of deferiprone (L1) and other iron chelators for clinical use: targeting methods and application prospects.
Curr Med Chem. 2004;11:2161-83.
 

Wound Healing and Management

K. Pattichis

Wounds: Pathophysiology, healing and management

Chemical News (Cyprus) 2000 30 17-24